https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38040 Wed 28 Jul 2021 10:17:50 AEST ]]> Clinical and Pathologic Factors Associated With Colonic Spirochete (Brachyspira pilosicoli and Brachyspira aalborgi) Infection: A Comprehensive Systematic Review and Pooled Analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54300 Wed 28 Feb 2024 15:46:42 AEDT ]]> A randomized, double-blind, placebo-controlled, phase 2b study of the efficacy and safety of velusetrag in subjects with diabetic or idiopathic gastroparesis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50274 70% of subjects receiving velusetrag 30 mg had GE normalization at 4 h. Treatment-emergent AEs were generally mild. Conclusions and Inferences: Velusetrag treatment was generally well-tolerated and associated with improved GE vs placebo in subjects with diabetic or idiopathic gastroparesis; however, only the lowest dose, velusetrag 5 mg, was associated with short-term improvement in gastroparesis symptoms.]]> Wed 28 Feb 2024 14:59:49 AEDT ]]> Alterations to the Duodenal Microbiota are Linked to Gastric Emptying and Symptoms in Functional Dyspepsia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50452 Wed 26 Jul 2023 13:14:54 AEST ]]> Development of a real-time patient-reported outcome measure for symptom assessment in patients with functional dyspepsia using the experience sampling method https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37120 Wed 24 May 2023 12:18:38 AEST ]]> Effects of antibiotic therapy in primary sclerosing cholangitis with and without inflammatory bowel disease: a systematic review and meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42463 p < 0.002) and smallest with metronidazole (22.7%, p = 0.18). Overall, 8.9% (95% confidence interval: 3.9-13.9) of patients had AEs severe enough to discontinue antibiotic therapy. In PSC patients, antibiotic treatment results in a significant improvement in markers of cholestasis and MRS. Antibiotics, particularly vancomycin, may have a positive effect on PSC either via direct effects on the microbiome or via host-mediated mechanisms.]]> Wed 24 Aug 2022 11:23:40 AEST ]]> A role for primary care pharmacists in the management of inflammatory bowel disease? lessons from chronic disease: a systematic review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38722 Wed 19 Jan 2022 09:36:08 AEDT ]]> Chronic constipation and co-morbidities: a prospective population-based nested case-control study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24679 Wed 17 Nov 2021 16:32:22 AEDT ]]> Duodenal inflammation: an emerging target for functional dyspepsia? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41179 Wed 12 Jul 2023 11:51:33 AEST ]]> Dysmotility symptoms are independently associated with weight change: a population-based study of Australian adults https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26276 Wed 11 Apr 2018 16:11:50 AEST ]]> Endoscopic full-thickness biopsy of the gastric wall with defect closure by using an endoscopic suturing device: survival porcine study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21656 Wed 11 Apr 2018 16:05:51 AEST ]]> Acid and non-acid reflux in patients refractory to proton pump inhibitor therapy: is gastroparesis a factor? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22234 4, respectively), the duration of acid and non-acid reflux in a 24-h period, and the number of reflux episodes lasting longer than 5 min. Results: No statistical difference was seen between the patients with GP and controls with respect to the total number or duration of acid reflux events, total number and duration of non-acid reflux events or the duration of longest reflux episodes. The number of non-acid reflux episodes with a pH > 7 was higher in subjects with GP than in controls. In addition, acid reflux episodes were more prolonged (lasting longer than 5 min) in the GP patients than in controls; however, these values did not reach statistical significance. Thirty-five patients had recorded symptoms during the 24 h study and of the 35 subjects, only 9% (n = 3) had a positive symptom association probability (SAP) for acid/non-acid reflux and 91% had a negative SAP. Conclusion: The evaluation of patients with a documented history of GP did not show an association between GP and more frequent episodes of non-acid reflux based on MII-pH testing.]]> Wed 11 Apr 2018 12:43:08 AEST ]]> Circulating anti-cytolethal distending toxin B and anti-vinculin antibodies as biomarkers in community and healthcare populations with functional dyspepsia and irritable bowel syndrome https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36083 Wed 05 Feb 2020 13:13:07 AEDT ]]> Diverticulosis, symptoms and colonic inflammation: a population-based colonoscopy study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47794 Tue 31 Jan 2023 15:19:00 AEDT ]]> Electroencephalographic evidence of unconscious and conscious attentional bias in people with functional gastrointestinal disorders: A pilot study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49759 Tue 30 May 2023 18:25:04 AEST ]]> Concentrations of fecal bile acids in participants with functional gut disorders and healthy controls https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49755 Tue 30 May 2023 17:42:46 AEST ]]> Comparison of Lactase Variant MCM6-13910 C>T Testing and Self-report of Dairy Sensitivity in Patients with Irritable Bowel Syndrome https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48117 Tue 28 Feb 2023 15:27:06 AEDT ]]> Eosinophilic colitis and colonic eosinophilia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47656 Tue 24 Jan 2023 15:26:41 AEDT ]]> Anti-TNFα therapy in IBD alters brain activity reflecting visceral sensory function and cognitive-affective biases https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47620 Tue 24 Jan 2023 13:48:44 AEDT ]]> Double-blind placebo-controlled study of rifaximin and lactulose hydrogen breath test in Gulf War Veterans with irritable bowel syndrome https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42447 P = 0.25) or QOL (all P = 0.26). Normalization of SIBO by LHBT was not different between rifaximin- and placebo-treated Veterans (7 vs. 22%, P = 0. 54). Conclusion: Rifaximin was not effective in improving IBS symptoms and QOL in GW Veterans with non-constipated IBS.]]> Tue 23 Aug 2022 11:08:19 AEST ]]> Compositional and functional differences of the mucosal microbiota along the intestine of healthy individuals https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38873 Bacteroides species and describe the antimicrobial resistance biogeography along the intestine. We also detail which species, at which locations, are involved with the tryptophan/indole pathway, whose malfunctioning has been linked to pathologies including inflammatory bowel disease. Our study thus provides invaluable resources for investigating mechanisms connecting gut microbiota and host pathophysiology.]]> Tue 22 Feb 2022 16:36:25 AEDT ]]> Celiac disease is uncommon in irritable bowel syndrome in the USA https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43080 Tue 13 Sep 2022 12:20:03 AEST ]]> Elevated serum tissue transglutaminase antibodies in children with eosinophilic esophagitis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33176 6× upper limit of normal (ULN) and 4 had >10× ULN. TTG Ab-positive patients were classified as having either potential CD with (n = 3, 16%) and without lymphocytic duodenosis (LD; n = 12, 63%), and no CD (n = 4, 21%) on human leukocyte antigen typing. There was an increase in duodenal eosinophils in patients with elevated TTG Ab (P = 0.01), which remained when patients with LD were excluded (P = 0.018). Of 19 patients with EoE and elevated TTG Ab, 5 responded to elimination diet involving exclusion of wheat, including 2 with a sole wheat trigger and TTG Ab >10× ULN that were CD-associated human leukocyte antigen-negative. Conclusions: Serum TTG Ab was elevated in almost one-quarter of our total EoE cohort, and at least 20% of these patients did not have potential CD, suggesting EoE is a heterogeneous disease with differing immune mechanisms activated in some patients. These findings also support routine esophageal biopsy during upper endoscopy in children with elevated TTG Ab.]]> Tue 11 Sep 2018 12:15:33 AEST ]]> Concomitant Irritable Bowel Syndrome Does Not Influence the Response to Antimicrobial Therapy in Patients with Functional Dyspepsia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46015 0.5). Conclusions: In FD patients, the response to antimicrobial therapy with rifaximin is not influenced by concomitant IBS symptoms.]]> Tue 08 Nov 2022 18:38:07 AEDT ]]> Association Between Anxiety/Depression and Gastroesophageal Reflux: A Systematic Review and Meta-Analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54155 Tue 06 Feb 2024 12:11:04 AEDT ]]> Cohort Profile: The Christchurch IBS cOhort to investigate Mechanisms for gut Relief and improved Transit (COMFORT) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50052 Thu 29 Jun 2023 15:41:37 AEST ]]> A GP primer to understanding biopsy reports of the lower gastrointestinal tract https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23037 Thu 28 Oct 2021 12:35:49 AEDT ]]> Duodenal eosinophils as predictors of symptoms in coeliac disease: a comparison of coeliac disease and non-coeliac dyspeptic patients with controls https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41178 Thu 28 Jul 2022 10:44:20 AEST ]]> Beyond Eosinophilic Esophagitis: Eosinophils in Gastrointestinal Disease-New Insights, "New" Diseases https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53983 Thu 25 Jan 2024 13:04:18 AEDT ]]> Epidemiology and pathophysiology of gastroparesis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42577 Thu 25 Aug 2022 14:35:16 AEST ]]> Duodenal bile acids as determinants of intestinal mucosal homeostasis and disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45598 Thu 23 Mar 2023 13:55:28 AEDT ]]> Duodenal bacterial load as determined by quantitative polymerase chain reaction in asymptomatic controls, functional gastrointestinal disorders and inflammatory bowel disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41177 Thu 18 Apr 2024 12:11:34 AEST ]]> Early infections and the risk of irritable bowel syndrome: a case-control study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37067 Thu 13 Aug 2020 12:05:44 AEST ]]> An increasing incidence of upper gastrointestinal disorders over 23 years: A prospective population-based study in Sweden https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46068 Thu 10 Nov 2022 14:23:04 AEDT ]]> Development of a symptom-focused patient-reported outcome measure for functional dyspepsia: the Functional Dyspepsia Symptom Diary (FDSD) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36113 Thu 06 Feb 2020 15:00:07 AEDT ]]> Effects of amitriptyline and escitalopram on sleep and mood in patients with functional dyspepsia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36111 Thu 06 Feb 2020 14:25:07 AEDT ]]> Eosinophilic gastroenteritis and other eosinophilic gut diseases distal to the oesophagus https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36110 Thu 06 Feb 2020 14:11:06 AEDT ]]> Duodenal pathology in patients with rumination syndrome: duodenal eosinophilia and increased intraepithelial lymphocytes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36102 Thu 06 Feb 2020 12:12:08 AEDT ]]> Duodenal eosinophilia is associated with functional dyspepsia and new onset gastro-oesophageal reflux disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36098 Thu 06 Feb 2020 11:23:06 AEDT ]]> Comorbidity of atopic diseases and gastro-oesophageal reflux: evidence of a shared cause https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49083 Thu 04 May 2023 09:25:22 AEST ]]> Diabetes mellitus is an independent risk factor for a greater frequency of early satiation and diarrhea at one and three years: Two prospective longitudinal population-based studies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50509 3 bowel motions a day (OR 1.50, 95% CI 1.08, 2.07, p = 0.02; OR = 1.67, 95% CI 1.11, 2.51, p = 0.01), and loose stools (OR 1.40, 95% CI 1.04, 1.90, p = 0.03; OR = 1.68, 95% CI 1.13, 2.51, p = 0.01) at the 1- and 3-year follow-ups, respectively. Conclusions & Inferences: Diabetes is an independent risk factor for a greater frequency of early satiation and diarrhea, adjusting for lifestyle and psychological factors.]]> Thu 03 Aug 2023 11:12:36 AEST ]]> Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49117 Thu 02 May 2024 12:18:23 AEST ]]> Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12377 Sat 24 Mar 2018 10:34:56 AEDT ]]> Efficacy of 5-aminosalicylates in ulcerative colitis: systematic review and meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12376 2.5 g/day do not appear to lead to higher remission rates.]]> Sat 24 Mar 2018 10:34:56 AEDT ]]> A link between physician-diagnosed ulcer and anxiety disorders among adults https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13977 Sat 24 Mar 2018 08:24:41 AEDT ]]> Challenges and lessons learned in conducting comparative-effectiveness trials https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12773 Sat 24 Mar 2018 08:18:20 AEDT ]]> Consensus statements for management of Barrett's Dysplasia and early-stage esophageal adenocarcinoma, based on a Delphi process https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12780 Sat 24 Mar 2018 08:18:20 AEDT ]]> An update on irritable bowel syndrome: from diagnosis to emerging therapies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13297 Sat 24 Mar 2018 08:18:05 AEDT ]]> Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12400 Sat 24 Mar 2018 08:15:46 AEDT ]]> Efficacy of immunosuppressive therapy for inflammatory bowel disease: a systematic review and meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12403 Sat 24 Mar 2018 08:15:46 AEDT ]]> 5-aminosalicylates prevent relapse of Crohn's disease after surgically induced remission: systematic review and meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12395 Sat 24 Mar 2018 08:15:45 AEDT ]]> Epidemiology and natural history of intestinal metaplasia of the gastroesophageal junction and Barrett's esophagus: a population-based study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12398 1cm with intestinal metaplasia) and IMGEJ (intestinal metaplasia in biopsies from the gastroesophageal junction) from 1976 to 2006 in Olmsted County, MN, were identified using Rochester Epidemiology Project resources. Demographic and clinical data were abstracted from medical records and pathology confirmed by gastrointestinal pathologists. The association of baseline characteristics with overall and progression-free survival was assessed using proportional hazards regression models. Outcome measures were baseline characteristics and overall survival of subjects with IMGEJ compared to those with BE. Results: In all, 487 patients (401 with BE and 86 with IMGEJ) were identified and followed for a median interval of 7 (BE subjects) to 8 (IMGEJ subjects) years. Subjects with BE were older, heavier, reported reflux symptoms more often, and had higher prevalence of advanced neoplasia than those with IMGEJ. No patient with IMGEJ progressed to esophageal adenocarcinoma (EAC) in contrast to BE subjects who had a cumulative risk of progression of 7% at 10 years and increased risk of death from EAC (standardized mortality ratio 9.62). The overall survival of subjects with BE and IMGEJ did not differ from that expected in similar age- and sex-distributed white Minnesota populations. Conclusions: Subjects with IMGEJ appear to have distinct clinical characteristics and substantially lower cancer progression risk compared to those with BE.]]> Sat 24 Mar 2018 08:15:45 AEDT ]]> Efficacy of biological therapies in inflammatory bowel disease: systematic review and meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12431 Sat 24 Mar 2018 08:15:28 AEDT ]]> An evidence-based systematic review on medical therapies for inflammatory bowel disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12436 Sat 24 Mar 2018 08:15:27 AEDT ]]> Efficacy of 5-aminosalicylates in Crohn's disease: systematic review and meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12432 Sat 24 Mar 2018 08:15:27 AEDT ]]> Eosinophilic gastroenteritis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10428 Sat 24 Mar 2018 08:13:17 AEDT ]]> Can professionalism be taught?: yes, but a more strategic approach should replace didactic methods https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17299 Sat 24 Mar 2018 08:01:46 AEDT ]]> Early life factors initiate a 'vicious circle' of affective and gastrointestinal symptoms: a longitudinal study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17257 Sat 24 Mar 2018 08:01:24 AEDT ]]> A randomly selected population sample undergoing colonoscopy: prevalence of the irritable bowel syndrome and the impact of selection factors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18602 Sat 24 Mar 2018 08:01:04 AEDT ]]> Acid-suppressive therapy with esomeprazole for relief of unexplained chest pain in primary care: a randomized, double-blind, placebo-controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19963 Sat 24 Mar 2018 07:58:34 AEDT ]]> Association between constipation and colorectal cancer: systematic review and meta-analysis of observational studies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19967 Sat 24 Mar 2018 07:58:34 AEDT ]]> A low response rate does not necessarily indicate non-response bias in gastroenterology survey research: a population-based study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19964 Sat 24 Mar 2018 07:58:33 AEDT ]]> Celiac disease, eosinophilic esophagitis and gastroesophageal reflux disease, an adult population-based study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19968 Sat 24 Mar 2018 07:58:31 AEDT ]]> Current and emerging pharmacotherapeutic options for irritable bowel syndrome https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19852 Sat 24 Mar 2018 07:57:05 AEDT ]]> Clinical value of duodenal biopsies: beyond the diagnosis of coeliac disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17888 Sat 24 Mar 2018 07:56:24 AEDT ]]> Atopy and the gastrointestinal tract - a review of a common association in unexplained gastrointestinal disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21293 Sat 24 Mar 2018 07:54:36 AEDT ]]> Anxiety disorders and risk of self-reported ulcer: a 10-year longitudinal study among US adults https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19307 Sat 24 Mar 2018 07:52:15 AEDT ]]> Duodenal eosinophilia and early satiety in functional dyspepsia: confirmation of a positive association in an Australian cohort https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20655 Sat 24 Mar 2018 07:49:58 AEDT ]]> Effect of amitriptyline and escitalopram on functional dyspepsia: a multicenter, randomized controlled study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27609 3-fold more likely to report adequate relief than those given placebo (odds ratio = 3.1; 95% confidence interval: 1.1-9.0). Neither amitriptyline nor escitalopram appeared to affect GE or meal-induced satiety after the 10-week period in any group. Subjects with delayed GE were less likely to report adequate relief than subjects with normal GE (odds ratio = 0.4; 95% confidence interval: 0.2-0.8). Both antidepressants improved overall quality of life. Conclusions Amitriptyline, but not escitalopram, appears to benefit some patients with FD, particularly those with ulcer-like (painful) FD. Patients with delayed GE do not respond to these drugs.]]> Sat 24 Mar 2018 07:39:41 AEDT ]]> Colonoscopy findings in high-risk individuals compared to an average-risk control population https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28377 Sat 24 Mar 2018 07:36:05 AEDT ]]> Anxiety is linked to new-onset dyspepsia in the Swedish population: a 10-year follow-up study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27399 Sat 24 Mar 2018 07:34:09 AEDT ]]> Emerging drugs for functional dyspepsia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27400 Helicobacter pylori testing and eradication is recommended. Based on currently available data, acotiamide appears promising, particularly in postprandial distress syndrome. Further large-scale multicentered trials are required to define the duration of treatment and the side-effect profile.]]> Sat 24 Mar 2018 07:34:09 AEDT ]]> Colonic spirochetosis is associated with colonic eosinophilia and irritable bowel syndrome in a general population in Sweden https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27132 Brachyspira in colonic biopsies, is uncommon and considered of doubtful significance. We aimed to determine the prevalence of CS in the general population, identify subtle colon pathologies, and evaluate a link with symptoms of IBS. Colonoscopy was performed in 745 subjects (aged 19-70 years, mean age 51 years, 43% male) with biopsies (ileum and 4 colonic sites) from a random population sample, Stockholm, Sweden, who completed a validated questionnaire of gastrointestinal symptoms; IBS was identified by Rome III criteria. CS was identified by histology and immunohistochemistry. In a general population, 17 individuals (2.28%; 95% confidence interval, 1.2%-3.5%) were diagnosed as having CS by histology; 6 (35%) had IBS. CS was always present in the sigmoid colon, but only 14 rectal biopsies. Eosinophils were increased in colon biopsies in CS cases versus controls, in the transverse (P =.02), sigmoid colon (P =.001), and rectum (P =.0005) with subepithelial eosinophil clusters (P =.053). Lymphoid follicles (at any site) were present in 13 CS (P =.0003). There was a 3-fold increased risk of IBS in CS (odds ratio, 3.59; 95% confidence interval, 1.27-10.11; P =.015). Polyps and diverticular disease were similar in CS cases and controls. The prevalence of CS in a general population is 2% and associated with nonconstipating IBS. Colonic eosinophilia with lymphoid follicles may signify the presence of CS.]]> Sat 24 Mar 2018 07:33:02 AEDT ]]> Assessing the presence and severity of constipation with plain radiographs in constipated palliative care patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30060 Sat 24 Mar 2018 07:31:19 AEDT ]]> Dyspepsia in the community: value of a community-based mailed survey to identify potential participants for a randomized clinical trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27822 Sat 24 Mar 2018 07:31:10 AEDT ]]> Epidemiology of gastroparesis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28539 Sat 24 Mar 2018 07:28:47 AEDT ]]> Efficacy of psychotropic drugs in functional dyspepsia: systematic review and meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31037 Sat 24 Mar 2018 07:25:48 AEDT ]]> Effects of birth cohorts on the irritable bowel syndrome support early-life risk factors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22752 Sat 24 Mar 2018 07:14:15 AEDT ]]> Dyspepsia and the microbiome: time to focus on the small intestine (letter) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24504 Sat 24 Mar 2018 07:13:11 AEDT ]]> Current status and advances in esophageal drug delivery technology: influence of physiological, pathophysiological and pharmaceutical factors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54589 Sat 02 Mar 2024 10:51:03 AEDT ]]> Effects of climate change on digestive health and preventative measures https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54035 Mon 29 Jan 2024 13:39:58 AEDT ]]> Development and Validation of a Patient-Reported Experience Measure for Gastrointestinal Endoscopy: The Comprehensive Endoscopy Satisfaction Tool (CEST) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51261 Mon 28 Aug 2023 14:59:19 AEST ]]> A serological diagnosis of coeliac disease is associated with osteoporosis in older Australian adults https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32805 Mon 23 Sep 2019 10:39:48 AEST ]]> Diverticulosis is not associated with altered gut microbiota nor is it predictive of future diverticulitis: a population-based colonoscopy study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53921 Mon 22 Jan 2024 16:42:54 AEDT ]]> Current and future approaches for diagnosing small intestinal dysbiosis in patients with symptoms of functional dyspepsia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51365 Mon 22 Apr 2024 11:57:52 AEST ]]> Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43435 P_app), with differences in ML retention and complexation amongst the chelants and the gut microbes. The decrease in ML permeability varied amongst the MLs. Chelating agents reduce intestinal absorption of MLs by forming complexes thereby making them less permeable. In the case of gut bacteria, the decrease in the intestinal permeability of MLs may be associated to a direct protection of the intestinal barrier against the MLs or indirect intestinal ML sequestration by the gut bacteria through adsorption on bacterial surface. Thus, both gut microbes and chelating agents can be used to decrease the intestinal permeability of MLs, thereby mitigating their toxicity.]]> Mon 19 Sep 2022 11:35:28 AEST ]]> Differential toxicity of potentially toxic elements to human gut microbes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51765 Cd > Pb > As(III)>As(V) for E. coli; and Hg > Cd > As(III)>Pb > As(V) for the two Lactobacillus sp. Arsenite (AsIII) showed higher toxicity than arsenate (AsV) to gut bacteria. While As is an anion, Cd, Pb and Hg are cations and hence their binding capacity to the bacterial cell wall varied based on the charge dependent functional groups. However, the toxic effects of PTEs for a bacteria are controlled by their speciation and bioavailability.]]> Mon 18 Sep 2023 14:23:29 AEST ]]> Effects of psychology and extragastrointestinal symptoms on health care use by subjects with and without irritable bowel syndrome https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48303 Mon 15 May 2023 10:42:18 AEST ]]> Ascending to new heights for novel therapeutics for eosinophilic esophagitis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53764 Mon 15 Jan 2024 09:56:13 AEDT ]]> Antibiotic use but not gastrointestinal infection frequently precedes first diagnosis of functional gastrointestinal disorders https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46215 Mon 14 Nov 2022 12:04:53 AEDT ]]> Circadian Rhythms and Melatonin Metabolism in Patients With Disorders of Gut-Brain Interactions https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53620 Mon 13 May 2024 12:39:54 AEST ]]> Emerging evidence that irritable bowel syndrome & functional dyspepsia are microbial diseases (editorial) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35708 Indian Journal of Medical Research, 149, April 2019, pp 437-440.]]> Fri 25 Oct 2019 15:19:19 AEDT ]]> Clusters of community-dwelling individuals empirically derived from stool diaries correspond with clinically meaningful outcomes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49999 Fri 23 Jun 2023 11:40:47 AEST ]]> Concentrations of Plasma Amino Acids and Neurotransmitters in Participants with Functional Gut Disorders and Healthy Controls https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51947 Fri 22 Sep 2023 17:06:11 AEST ]]> Does the microbiome play a role in the pathogenesis of colonic diverticular disease? A systematic review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51590 Fri 22 Sep 2023 13:41:03 AEST ]]> A GP primer for understanding upper gastrointestinal tract biopsy reports https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24284 Fri 18 Nov 2016 10:49:49 AEDT ]]> Eosinophils, hypoxia-inducible factors, and barrier dysfunction in functional dyspepsia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53126 Fri 17 Nov 2023 12:21:21 AEDT ]]> Discriminant and convergent validity of the GSRS-IBS symptom severity measure for irritable bowel syndrome: a population study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39693 Fri 17 Jun 2022 16:07:04 AEST ]]> Effect of the gluten-free diet on cardiovascular risk factors in patients with coeliac disease: A systematic review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44360 Fri 14 Oct 2022 08:44:33 AEDT ]]> Duodenal eosinophilia and the link to anxiety: A population-based endoscopic study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49401 Fri 12 May 2023 14:41:29 AEST ]]>